competitive inhibition
从而阻止底物与酶结合
常用释义
英式发音
美式发音
基本释义
- 竞争性抑制：一种酶抑制剂的作用方式，它通过与酶的活性部位竞争结合，从而阻止底物与酶结合，降低酶的催化活性。
例句
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1·The paratope mapping of antibodies was determined by competitive inhibition in radioimmunoassay.通过放射免疫测定中的竞争性抑制来确定抗体的互补位图。
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2·Meanwhile, many drugs can influence the activity of CYP2D6 by competitive inhibition or induction, which is easy to cause interaction in coadministration.而且CYP2D6能被多种药物竞争性抑制和诱导，药物联用时易产生相互作用。
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3·Methods: the colloidal gold strip for specific sulfadimidine was developed successfully on the basis of competitive inhibition immunochromatography mechanism.方法：应用竞争抑制免疫层析原理，研制磺胺二甲基嘧啶胶体金试纸条。
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4·In the competitive inhibition experiment, it showed that rapamycin and FK506 could bind this protein competitively and rapamycin had better binding capacity than FK506.竞争性抑制实验显示雷帕霉素与FK506和该蛋白质的结合存在竞争性，且雷帕霉素与该蛋白质的结合能力比FK506强。
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5·QU exhibited competitive inhibition of CYP3A2 dextromethorphan N-demethylation reaction and expressed noncompetitive inhibition of CYP2E1 chlorzoxazone-6-hydroxylation reaction.槲皮素竞争性抑制CYP3A 2右美沙芬N脱甲基反应，非竞争性抑制CYP2E1氯唑沙宗6羟化反应。
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6·METHODS The paratope mapping of antibodies was determined by competitive inhibition in radioimmunoassay and the sequences of variable regions among the antibodies were compared.应用放射免疫竞争抑制试验测定抗体的配位特异性，并对抗体的可变区序列进行比较。
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7·Competitive INHIBITION Competitive inhibitors compete with substrate for an enzyme's active site, lowering the enzyme's likelihood of binding substrate and slowing the observed reaction velocity.竞争性抑制竞争性抑制剂与底物竞争酶的活性部位，降低酶的约束力基板的可能性，并观察到的反应速度放缓。
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8·Kinetic studies of AG114 inhibition on recombinant human CK2 showed that the inhibition was mixed competitive with GTP and noncompetitive with casein.AG114对重组人ck2的动力学研究表明：它与GTP呈混合竞争性抑制作用，与酪蛋白呈非竞争性抑制作用。
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9·Kinetic studies of AG1112 on recombinant human CK2 showed that the inhibition was mixed (competitive is dominant) with GTP and noncompetitive with casein.AG 1112对重组人ck2的动力学研究表明：它与GTP和酪蛋白分别呈混合性和非竞争性抑制作用。
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10·A kinetics model was developed for predicting and simulating immobilized cellulase performance, which follows Michaelis_Menten kinetics with competitive product inhibition.建立了固定化纤维素酶的反应动力学模型，该模型以米氏方程为基础并考虑了产物竞争性抑制的影响。