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1·To substitute the ring a of the aurones with pyrimidine, a series of aza aurones were synthesized.

2·The calculated results show that the aza Wittig reaction is a two step reaction, having one four membered ring intermediate on its reaction surface.

3·Then it was observed whether the inactived genes in leukemia cell lines were actived after the treatment with 5-aza-deoxycytosin, a kind ofdemethylation agent .

4·The invention relates to compounds of a general formula (1) and pharmaceutically acceptable salts, and mainly discloses 4'-substituted 13-cyclo-aza-lactone derivatives.

5·Compared with AZA, MMF also is an alternative for maintenance therapy of severe LN without significant difference in the prognosis or risks of amenorrhoea and herpes zoster.

6·Methods The survival rate and apoptosis rate of QBC939 after being treated with different density of 5-aza-2'-deoxycytidine were detected by using the method of MTT and flow cytometry.

7·The efficacy of hypomethylating agents (e. g. 5 aza 2′ deoxycytidine) as antineoplastic agents has been attributed to two distinct mechanism: cytotoxicity and induction of hypomethylation.

8·The dissertation mainly involves in synthesis of chiral aza crown ethers and includes the following aspects of content:1. Synthesis and structural characterization of chiral aza crown ethers.

9·The nitrogen hetero atomic shape structure is aza big ring or aza condensed ring or nitrogen hetero atomic ring shape conjugate symmetry or nitrogen hetero atomic ring shape conjugate asymmetry.